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First, AOD-9604 activates beta-3 adrenergic receptors on fat cells, triggering the cAMP-PKA cascade that activates hormone-sensitive lipase

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In vivo , 5-amino-1MQ-treated mice had significantly reduced body weights, white adipose masses, and adipocyte sizes

Several pathways have been shown to be involved in the regulation of mitophagy, but the precise underlying molecular mechanisms remain elusive (Fig

Pumpo R, Sarnelli G, Spinella A, Budillon G, Cuomo R (2001) The metabolism of nicotinamide in human liver cirrhosis: a study on N -methylnicotinamide and 2-pyridone-5-carboxamide production