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In addition to the nucleus, activated STAT3 can also be taken up into mitochondria, where it promotes mitochondrial functionality and maintains mitochondrial membrane potential 38

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Lead is known to efficiently penetrate the bloodbrain barrier and it quickly replaces calcium ions, thereby interfering with the regulation of brain cell activity by calcium and therefore causing a disruption of various intracellular processes

It decreases with age or chronic disease even though we need the same amount of glutathione throughout our lives