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If it spreads or worsens, you may want to contact your healthcare provider as this could point to an allergic reaction

SCD erythroid progenitors were cultured in a modified two-phase liquid culture system 24

Antibodies used were: anti-keratin 16 (sc-53255, Santa Cruz)

10.1146/annurev.arplant.55.031903.141701 5 AsadaK

J Cell Physiol 234:1216112172

Generally safe, side effect is usually constipation (which you may already have)