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J Agric Food Res 14:100834

Effect of delayed-release dimethyl fumarate on no evidence of disease activity in relapsing-remitting multiple sclerosis: integrated analysis of the phase III DEFINE and CONFIRM studies

Nitric oxide system modulation

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Subsequent studies have found that UA exhibits neuroprotective effects on dopaminergic neurons in experimental PD models by suppressing neuroinflammation and oxidative stress through activation of the Nrf2-ARE antioxidant defense mechanism [176]

The induction of diabetes mellitus significantly elevated blood pressure, HbA1c, BUN, creatinine, and renal tissue levels of MDA, whereas SOD, CAT and GPx activities were significantly reduced