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Poster Session II - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.04 - THROMBOLYSIS P622 - ESOC25-554 A MULTICENTER, PROSPECTIVE, RANDOMIZED, OPEN-LABEL, BLINDED-ENDPOINT TRIAL OF TENECTEPLASE FOR ACUTE NON-LARGE VESSEL OCCLUSION IN EXTENDED TIME WINDOW (OPTION): RATIONALE AND DESIGN Ran Mo 1 , Gaoting MA 1 , Junwei Hao 1 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China Background and Aims: Intravenous thrombolysis, the standard of care for acute ischemic stroke (AIS) within 4.5 hours of symptom onset, is generally not offered to patients presenting beyond this time window