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These rare genetic conditions prevent normal copper processing and could lead to accumulation

10.1016/j.celrep.2021.109960 131 XuB.WangZ.LiG.LiB.LinH.ZhengR.et al (2006)
Monitoring nutrient status while on tirzepatide with B12 Baseline laboratory assessment before starting tirzepatide should include B12 levels, complete blood count (CBC), comprehensive metabolic panel (CMP), lipid panel, and HbA1c if you have diabetes or prediabetes

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doi: 10.1073/pnas.1118046108
