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Cyanocobalamin is a form of vitamin B12 derived from cyanide and should be avoided

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In conclusion, the current findings prove that carnitine replacement to restore its homeostasis is a golden strategy to prevent as well as attenuate methotrexate induced organ toxicity via reversing its impact on ACC1, ATP levels, and kidney and liver functions

So far, most discussed compounds have shown good safety profiles in studies, but ongoing vigilance is required

Asian Pac J Allergy Immunol 25(1):1725 Shen YL, Jin X, Chen W et al (2020) Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses