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Most of the tools currently used to study the permeability of nanocarriers to the BBB, drug quantification, and their safety and efficacy assays are indirect or destructive

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Biogerontology 2016;17, 305-315, doi:10.1007/s10522-015-9610-z

This observation was mechanistically determined to be in part due to A 142 binding directly to COX1 and inducing loss of enzymatic activity of the greater mitochondrial electron transport chain complex 4 (C4), of which COX1 is an integral part

Among the clones, z13, which displayed the sequence VRRADNRPG, was the strongest binder

However, the comparison is not strictly either-or