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Oxidized LDL is more atherogenic, meaning it is more likely to contribute to atherosclerosis (hardening of the arteries) than normal LDL

Fernando IPS, Jayawardena TU, Kim HS, Lee WW, Vaas APJP, De Silva HIC, et al

10.4014/jmb.1202.02028 Yoon HS, Shin SY, Kim YS, Kim IS: Glutathione reductase from Brassica rapa affects tolerance and the redox state but not fermentation ability in response to oxidative stress in genetically modified Saccharomyces cerevisiae

Moreover, adverse effects such as nasal irritation and epistaxis (nosebleeds) can further discourage patients from adhering to their treatment plans [5]

Hormones (Athens) (2014) 13:40712

209 Some supplements contain P5P, which raises P5P levels and appears less likely to contribute to nerve problems than pyridoxine