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Indeed, these results suggest that Nrf2 acts as a tumor suppressor at an early stage and as an oncogene at a later stage.28 The same group also showed that the growth of urethane-induced lung tumors is attenuated in Keap1 knockdown mice, thereby avoiding carcinogenesis

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The protein concentration was determined by an enhanced BCA protein assay kit (Beyotime)

Carcinogenesis 17 347353 Douki T, Martini R, Ravanat JL, Turesky RJ and Cadet J 1997 Measurement of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxo-7,8-dihydroguanine in isolated DNA exposed to gamma radiation in aqueous solution

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Brennan P., Babbage J.W., Burgering B.M., Groner B., Reif K., Cantrell D.A

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