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The data were collected from Harmony 4.8 (Perkin Elmer) and the fluorescent intensity was measured by the ImageJ (1.53) software, placing 10 regions of interest in randomly selected areas

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Comparison of the spatial firing patterns of CA1 and CA3 neurons in aged memory impaired rats showed that aged CA3 cells failed to rapidly encode new spatial information compared with young CA3 cells while CA1 place cells in aged and young rats had similar firing characteristics (Wilson et al., 2005)

REDEFINE 1 Results (Phase 3) The landmark trial randomized 3,417 adults to CagriSema 2.4/2.4 mg, semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, or placebo for 68 weeks (Aronne et al., 2025): The combination significantly outperformed either component alone