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Upon stimulation with phenylephrine, both subtypes induce rapid phosphorylation of ERK1/2 through activation of PKC, which leads to ERK1/2 translocation to the nucleus

The model of zebrafish has been also used for group-3 MB cells (130) to identify the subgroup MB cellular origin (131), to mimic the SHH-MB with specific mutations (132), to generate transcription activator-like effector nucleases TALEN-mediated somatic gene inactivation of CDKN2A/B or RB1 tumor suppressor genes (133)

Clark, I.E.*, Romero-Calderon, R.*, Olson, J.M., Jaworski, L., Lopatto, D

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