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10.1002/ijc.31092 68 SuX.YangY.GuoC.ZhangR.SunS.WangY.et al (2021)

Anthonymuthu, T

In the prevalent non-amyloidogenic pathway, APP is cleaved by the membrane-bound enzyme -secretase [125] within its A domain, resulting in the formation of extracellular secretion of neuroprotective soluble APP (sAPP) fragments [126] and short a membrane-bound C-terminal fragment (CTF or -CTF or C83) followed by -secretase cleavage of C83 to form a 3 kDa peptide (p3) with release of the APP intracellular domain (AICD) into the cytoplasm [127, 128]

Not exactly a ringing endorsement

Q.GaoY.GaoY.ChenA.et al (2025)

Moreover, heavy metals could be a critical factor that triggers PCS phosphorylation [56, 69]
