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Common Side Effects Injection site redness and warmth are the most frequent complaints

What often surprises people is that the psychological symptoms (the depression, anxiety, difficulty sleeping, low motivation, and cravings) can continue long after the physical ones are gone

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2020 doi: 10.1016/j.livres.2020.10.003

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Since both aging and obesity are linked to elevated plasma insulin levels, a potential mechanism underlying these effects may involve increased insulin activity on hypothalamic and/or pituitary IGF-I receptors