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Here, Paul Yen and colleagues describe and summarize the key features of direct thyroid hormone regulation of lipogenesis, fatty acid -oxidation, cholesterol synthesis and the reverse cholesterol transport pathway in normal and altered thyroid states.

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Currently, temozolomide (TMZ) is the first-line drug for GBM treatment of which efficacy is unfortunately hindered by short circulation time and drug resistance associated to hypoxia and redox tumor microenvironment

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