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The "frizzled feather" phenotype, which features outwardly curled feathers, was first documented by Darwin and is associated with better heat dissipation

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Probiotics like Lactobacillus plantarum and Bifidobacterium bifidum can activate AMPK/Nrf2 signaling, reducing hepatic oxidative stress and improving lipid metabolism in MASLD

The goal is eliminating the infection source so healing can restart not removing the foot

Probiotics work through several methods, including gut flora alteration, intestinal mucosa barrier strengthening, pathogen colonization decrease, inhibition of enhanced immune response, and generation of short-chain fatty acids, amino acids, vitamins, and enzymes, among others

6PR and Supplementary Fig