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I think you look at the data for that, not just for joint health, for someone whos interested in either preventing joint problems or dealing with them but also for all-cause mortality, surprisingly, a lot of these studies have shown that thats like number one in reducing all-cause mortality, and these studies are lower all-cause mortality

X.FliersE.et al (2011)

Chemical, manufacturing, and standardization controls of grape polyphenol dietary supplements in support of a clinical study: mass uniformity, polyphenol dosage, and profiles

Cheng, Y., Zak, O., Aisen, P., Harrison, S

The most common digestive side effect is mild nausea, affecting 5-10% of users