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Description
Postnatal maternal deprivation produces long-lasting modifications of the stress response, feeding and stress-related behaviour in the rat
The problem with it though is that it can also sensitize and irritate the skin quite easily when it comes in leave-on formulas

8 , e1000481 (2010)

10.1038/s41590-022-01185-3

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For more severe cases or when systemic inflammation is significant, combining both provides broader coverage