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Description
Slices cover more anatomy but have the disadvantage of including several different types of tissue within the same slice (i.e., white matter, gray matter, blood vessels, and ventricles/cerebrospinal fluid)

CONTROVERSIES Prior work from our lab has identified GDF11 as a target of interest in aging-related dysfunction [12,14,15,80,81]
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Mice lacking the modifier subunit ( Gclm/ mice) are viable and fertile and have no overt phenotype under basal conditions

S2CID 7799814

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They are easily adaptable to high-throughput screens which enable large numbers of compounds to be screened rapidly and inexpensively
