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It had advanced into clinical trials as an anti-atherosclerotic agent, although it failed in a phase III trial (Muldrew and Franks, 2009)

The in vivo antioxidant effect not only induces a morphological protective effect on lung tissue but also effectively increases SOD activity in vivo and reduces the MDA content, thereby reducing the damage to lung tissue caused by the large amount of oxygen free radicals in tobacco ( 4.7 Antimalarial Malaria, caused by Plasmodium vivax , poses a major health threat to the majority of the worlds population (Thao et al., 2015)

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To overcome the difficulties in targeting NRF2 for controlling NRF2-addicted cancers, targeting metabolic liabilities unique to NRF2-addicted cancer cells, such as dependency on exogenous NEAAs, including glutamine, is a very sensible way to achieve selective toxicity toward cancers that have fallen in NRF2 addiction

Further mechanism studies confirmed that Lico-A effectively inhibits P

doi: 10.1126/science.aai8185 27 BishtK.SharmaK
