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Chronic inflammation, in turn, enhances the expression of pro-fibrotic factors via the activation of pathways like NF-B, damaging atrial intercellular junction proteins (e.g., Cx40 and Cx43) and affecting electrical signal transmission in the myocardium (Karam et al., 2017)
Exceptions to these are two short chain peptide-related drugs, bortezomib and mifamurtide [21, 22]
Yamada, N
Xenotransplantation (2019) 26:E12498
Although the results were beneficial, they proposed combining Argireline and Leuphasyl because of their different mechanisms of action, resulting in a more long-lasting effect [25]
