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Given the drugs success in tumor penetration, the researchers investigated whether adding immune checkpoint inhibitors to treatment with the drug would be even more effective, taking the brakes off T cells in more than one way at the same time but there was no such improvement

(2024): A pilot study of 12 women with severe interstitial cystitis who had not responded to pentosan polysulfate (the only FDA-approved treatment)

CIP2A inhibits PP2A, whereas 4HNE activates PP2A 63

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Cysteine cross-linking and western blots For western blots, HEK293T cells were cultured for 48 hrs post-transfection

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