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For instance, metformin, is generally well-tolerated but can cause gastrointestinal side effects (e.g., nausea, diarrhea) and, in rare cases, lactic acidosis, particularly in patients with renal impairment [118]

Specifically, it upregulates specific microRNAs (miRNAs) to silence the expression of two critical molecules: miR-155, miR-181b, and miR-361 target Aicda, whereas miR-23b, miR-30a, and miR-125b target Prdm1 (encoding B lymphocyte-induced maturation protein-1, Blimp-1)

Peptides are generally considered safe for hair growth applications

Limitations: It is uncertain that the members of the control group were totally disease-free

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