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Importantly, interindividual variability in microbiome composition, driven by diet, geography, host genetics, antibiotic exposure, and age, remains a key barrier to reproducibility and complicates the development of universally applicable diagnostic and therapeutic tools

Such combinatorial therapies lead to increased incidences of adverse effects like diarrhoea, lactic acidosis, and hepatotoxicity which leads to a decline in patient compliance (52, 53)