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Macrocyclic lactone Rapamycin, a macrocyclic lactone isolated from Streptomyces hygroscopicus , is known for its immunosuppressive and antimicrobial properties due to its ability to inhibit the mTOR pathway, thereby promoting autophagy [63]

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CaMKII is actually a family of four serine/threonine kinases, CaMKII, CaMKII, CaMKII, and CaMKII, each of which is encoded by a separate gene

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The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events