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61% of patients have reported being bedbound on their worst days (41) and at least one-quarter of ME/CFS patients have recounted being housebound or bedbound at some point in their lives (2)
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Our hypothesis focuses primarily on the putative metabolic consequences of this interaction (i.e., depletion of serum holoTC and elevations in tHcy and MMA)
This process may be confounded by gut -glucuronidases produced by Bacteroidetes that cleave glucuronide conjugates, releasing free xenobiotic compounds and glucuronic acid that are utilized as energy sources
Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
We then refined it by subcellular location
