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Glutathione reductase (GR) is a crucial enzyme within the cellular redox system responsible for maintaining cellular levels of reduced GSH [26]

Though exogenous methylglyoxal can induce LGSH accumulation in parental lung cancer cells (Supplementary Fig

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As discussed earlier, PRDX6 binds GPX4 through a Cys47-mediated disulfide bond, facilitating GPX4 localization to cellular membranes and enhancing lipid peroxide detoxification 100

Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation

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