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Probiotics are usually indigestible dietary carbohydrates that promote the growth and function of beneficial microorganisms in the gastrointestinal tract (43)

Systematic reviews and comparative PK studies confirm that specialized curcumin preparations can increase systemic exposure versus unformulated curcumin, but the magnitude of the increase depends strongly on formulation type, dose, and the analytic method used to quantify free versus conjugated curcuminoids

doi:10.1016/j.bcp.2004.06.013 Shin MJ, Kim DW, Lee YP, Ahn EH, Jo HS, Kim D-S, Kwon O-S, Kang T-C, Cho Y-J, Park J, Eum WS, Choi SY (2014) Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury

Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells

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This ensures that phytochemicals, such as curcumin, remain intact during circulation/BBB transit but unleash at disease sites (acidic/inflamed brain regions), amplifying Nrf2/antioxidant effects in AD/PD models with minimal off-target toxicity