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Intriguingly, quantification of the numbers of neurons in the myenteric plexus of germ-free versus SPF mice revealed a significant reduction in numbers in the duodenum and ileum but not in the colon, which seems somewhat counterintuitive and not readily explicable to this point

Considering the apparent similarity of these models with corresponding human conditions, NaBPC157 can be used for the treatment of hypertension and various organ damages caused by hypertension

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Selgrad M, De Giorgio R, Fini L, Cogliandro RF, Williams S, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Genta RM, Domiati-Saad R, Meyer R, Goel A, Boland CR, Ricciardiello L

Perspective article: growth factors and cytokines in wound healing