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Metformin, widely prescribed for type 2 diabetes, can impair B12 absorption through effects on calcium-dependent ileal uptake
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97 discovered that -catenin interacted with hif-1 to promote hif-1 signaling and to suppress Wnt/-catenin signaling, together leading to an exaggerated EMT in hypoxic HCC

Medium term post-bariatric surgery deficit of vitamin B12 is predicted by deficit at time of surgery

Roemmich JN, Clark PA, Weltman A, Veldhuis JD, Rogol AD
