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It must be used with extreme caution in patients with Th1-dominant autoimmune diseases (e.g., MS, Rheumatoid Arthritis, Hashimoto's) as it could theoretically cause a flare

Varghese for contributions that allowed us to generate Supplementary Fig

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In addition, we have mentioned the protective role of mitochondrial ALDH2 against oxidative stress-mediated mitochondrial dysfunction and hepatotoxicity, apoptosis/necrosis of hepatocytes and gut enterocytes, the production of DAMPs, the activation of Kupffer cells and HSCs, altered inflammation, and fibrosis, leading to cirrhosis and HCC

To maintain any benefit, you need treatments 1-3 times per week, indefinitely

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