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Description
Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

Practitioners recommend NAC to help enhance the bodys antioxidant defenses & reduce oxidative damage

Johns wort is another supplement to avoid

Gut microbiota Recent studies have demonstrated that gut microbiota is involved in pain modulation [136], and the different types of peripheral neuropathies induced by OHP in both the c mice and germ-free (GF) mice have indicated that the gut microbiota is critical to the induction and pathogenesis of OIPN [83]

The Aging Process Natural production of glutathione begins to decline as we age

The injection frequency is low enough that the marginal comfort difference does not matter as much
