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Description
Mounjaro (tirzepatide) is a prescription medication licensed by the MHRA for the treatment of type 2 diabetes mellitus and for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity
This directly validates the biological mechanisms identified in the foundational 2007 Pyo et al
70 BCKDK inhibitors are also effective in attenuating insulin resistance in mouse models of obesity, and the development of a new generation of more powerful BCKDK inhibitors is important for diseases that require inhibition of BCAA catabolism
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Annu Res Rev Biol 2017;11:1-8 10.9734/ARRB/2016/31711 [DOI] [Google Scholar] 62
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