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Although combined inhibition of SLC7A11 and GLS has been shown to induce apoptosis and ferroptosis more effectively than targeting either alone in TNBC cells [11], our data show a different outcome
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Small-molecule inhibitors of the GSH pathway, such as buthionine sulfoximine (BSO), block -glutamylcysteine ligase and GSH biosynthesis, thereby exacerbating the oxidative stress elicited by radiotherapy and cisplatin [214,215,216]
17: 40614 Sato AK, Sexton DJ, Morganelli LA, et al
b , Structure of teixobactin with the NMR assignments
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