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It suggests a shift in how the body spends energy rather than appetite suppression, which is the opposite of how GLP-1 drugs drive weight loss
This resistance is often tied to changes within fat cells themselves, including the activity of a key metabolic enzyme known as NNMT
Some patients don't realize how depleted they felt until after starting supplementation
Phase 2 trials (Jastreboff et al., NEJM, 2023) have shown it to be highly effective for weight reduction in adults with obesity
When pernicious anaemia is suspected, testing for anti-intrinsic factor antibodies (and sometimes anti-parietal cell antibodies) is recommended
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