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On pure tendinopathies, the combo outperforms TB-500 alone in the majority of documented equine veterinary protocols

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As B12 has a central role in methylation, further epigenetic studies are required to determine tissue-specific methylation changes related to lipid and inflammation pathways and metabolic phenotype

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The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

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