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Noguera, A

Individuals with polymorphisms in the vitamin D receptor gene associated with reduced receptor expression in oesophageal tissue have been found to have lower incidences of reflux oesophagitis, Barretts oesophagus and oesophageal adenocarcinoma (Reference Janmaat, van de Winkel and Peppelenbosch120)

A few theories have been proposed to explain this: 1) type II muscle fibers mainly rely on glycolysis and females have smaller type II fibers than men [95, 96]

2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation (Tan and Song, 2023),these damages further lead to mitochondrial dysfunction, which in turn prompts more ROS production, forming a positive feedback loop (Tan and Vlajkovic, 2023)