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doi: 10.1186/s12935-014-0124-6
doi: 10.1016/j.micpath.2016.12.006 37 GottliebO
76 Familial AD (FAD) is predominantly characterized by autosomal dominant genetic mutations in amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2) genes, typically manifesting between 30-65 years and progressing rapidly
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The catalytic glutamate residue E 115 accepts a proton from the -glutamyl group of the substrate, initiating a nucleophilic attack by the amine on the amide carbon atom
doi: 10.1038/s41598-023-32752-9 168
