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Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism

Zhu, Jinlong, Zhenyu Liao, Kai Chi Yam, and Russell E

[Google Scholar] Devi, K

The synthesis of the CoQ10 molecule comprises three major steps, namely, synthesis of the benzoquinone structure from 4-hydroxybenzoate (derived from either tyrosine or phenylalanine), synthesis of the polyisoprenoid side chain from acetyl-coenzyme A (CoA) via the mevalonate pathway, and condensation of these two structures to form coenzyme Q10

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcription factor upregulating the antioxidant response element (ARE)-mediated expression of antioxidant and detoxifying enzymes, and the Nrf2-antioxidant pathway is critical in host defense against acute lung injury (ALI) 24

Enhanced -synuclein toxicity is epistatically regulated by the PARK6 homolog, pink-1 Given that altered proteasome, protein mishandling, and GSH deficiencies associate with mitochondrial dysfunction in sporadic PD, 11, 20, 21, 32, 36 we sought to understand how metabolite-induced proteasome inhibition relates to PINK1 and Parkin