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Yes, continuous exposure can desensitize surface receptors, so most protocols incorporate "on" and "off" cycles to maintain biological response and prevent antibody buildup

Warnings Do not exceed the recommended daily dose

Magnetic Resonance in Medicine, 25(1), 94106

When restarting, patients return directly to the maintenance dose of 20 units (2.0 mg) daily

"Sirturo (bedaquiline) Tablets
