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Procyclin D inhibitors, such as Debio-025, have been demonstrated to reduce mPTP opening and protect cardiomyocytes [139]
It is a two-step research sequence: first SS-31 to target cardiolipin and mitochondrial membrane stability, then MOTS-c to study AMPK-linked metabolic adaptation
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Non-responders exist in every treatment population
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10.1016/S1470-2045(12)70490-4 Lancet Oncol
