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Oncotarget 8 (33), 5495154965

J Cereb Blood Flow Metab 31:13541370

2019 Update: My vitamin B12 recommendations have changed to reflect the latest science and labeling changes

Not necessary, but refrigeration is acceptable if it prevents temperature fluctuations (never freeze)

I am a somewhat regular user and usually will use for 2 months and then cycle off for a month or the results I see seem to diminish

Lei J, Sun L, Huang S, et al