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Although cytokines are mainly produced by the immune system, there is also an unclear link between neuroinflammation and these peripheral proinflammatory cytokines (46) and some cytokines may also be produced in the CNS (201)

This matters for people whose bodies struggle to absorb B12 through food, since an injection skips the digestive absorption step that oral supplements depend on

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Convenient for daily supplementation

Vitamin B12 injections bypass the digestive tract and deliver cobalamin directly into muscle or fatty tissue, which is why healthcare providers often recommend them for people with pernicious anemia, malabsorption conditions, gastric bypass history, strict plant-based diets, or age-related B12 decline