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Phase I trial of docetaxel administered as a 1-hour infusion in children with refractory solid tumors: A collaborative pediatric branch, national cancer Institute and children's cancer group trial

doi: 10.1161/CIRCULATIONAHA.120.048996 28

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This reduces the leaf internal CO 2 , which leads to the formation of ROS such as hydroxyl radicals (OH) singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), alkoxyl radical (RO) and superoxide radical (O 2 ) mainly by enhancing electrons leakage to oxygen molecule 1,2,3,4

The PI3K signaling pathway is dysregulated in many tumors, and analyses have shown that PIK3CA is an oncogene that also contributes to tumor progression partially via metabolic reprogramming 188