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This has been hypothesized as either due to blood bacteremia from oral pathogens entering the blood via the bleeding gums and thus crossing of the blood brain barrier and/or entry to the brain via the trigeminal nerves (Teixeira et al., 2017

[DOI] [PMC free article] [PubMed] [Google Scholar] 423.Rajendran P., Li F., Manu K.A., Shanmugam M.K., Loo S.Y., Kumar A.P., Sethi G

Proc Natl Acad Sci U S A 107:1556570

Owing to their nanoscale dimensions (10100 nm), micelles exhibit enhanced penetration through the permeable vasculature via the EPR effect, enhancing their utility in targeted delivery applications, particularly in pathological tissues (113)

Environ Pollut 238:7684

Epitalon Epitalon, also commonly known as Epithalon peptide or Epithalone is a synthetic tetrapeptide with four amino acids in its structure