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The pathophysiological mechanisms of BTHS are poorly understood, and treatments remain symptomatic

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Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals between cells and their environment in a wide range of states in health and diseases

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This Review examines sex in IBD pathophysiology and clinical manifestation and provides a frame for improving clinical and preclinical IBD studies by considering sex an essential factor.

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