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Summary Keywords amodiaquine, quinoneimine, cytotoxicity, endoplasmic reticulum stress, human glutathione S -transferases P1 Citation Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM and Vos JC (2018) Glutathione S -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

These results suggested that all of the three proposed mutations play deleterious role and may be linked with the GPx1 overexpression

Their paper, Glutathione peroxidase activity is neuroprotective in models of Huntingtons disease , was published in Nature Genetics

The difficulties with ultrasound relate to the lack of knowledge about the mechanism by which it works, along with factors relating to safety, efficacy and timescale (such as how long the barrier is open)