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Additionally, studies have found that gut microbiota plays an important role in regulating motor dysfunction [12]

Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(ALPHA) Subunit expression that correlate with enhanced tau phosphorylation

Finally, in transgenic rats, GLT-1 expression and function were significantly increased in the ipsilateral dorsal region of the lumbar spinal cord [303], which seemed surprising, however, this could be associated to differential expression in astroglia and microglia, as it was previously reported after pSNL in the above study[246]

Mediolateral extent PEG-fused animals reliably exhibited terminal labeling (22 out of 23 cases) within the correct mediolateral boundaries established in Unoperated Control animals ( Figure 5B )

Dystonia described in these patients had mostly two patterns- 1) Insidious onset lower limb dystonia occurring more in the older population (5 th 6 th decade) [ 47 ] and 2) Subacute onset craniocervical dystonia in middle-aged patients [ 48 , 49 ]