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In F344 rats, the administration of high doses of GA orally for a period of 14 weeks, at a dosage of 357 mg/kg/day for males and 384 mg/kg/day for females, resulted in the induction of significant toxic effects in both sexes

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Adolescents aged 1114 years require 1.2 g, increasing to the adult dose of 1.5 g from age 15 onwards