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CoQ 10 triggers mitochondrial biogenesis against oxidative stress To determine whether oxidative stress triggers alteration of the intracellular mitochondrial network in ONH astrocytes and whether CoQ 10 treatment inhibits this alteration in mitochondria against oxidative stress, the mitochondrial morphology of ONH astrocytes were assessed by MitoTracker Red (Invitrogen-Molecular Probes, Eugene, OR, USA) staining, a marker for mitochondria

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Establishment of comprehensive mechanistic models that incorporate mitochondrial oxidative stress, lipid metabolic reprogramming, and inflammatory amplification, to enable pathway-synergistic targeting

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doi: 10.1016/j.jasms.2006.07.010